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KMID : 0376319930050010211
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Dental Journal of CNU
1993 Volume.5 No. 1 p.211 ~ p.233
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COMPARATIVE STUDY OF HISTOPATHOLOGIC, FLOW CYTOMETRIC, AND CLINICAL PARAMETERS FOR THE PROGNOSTIC EVALUATION OF ORAL SQUAMOUS CELL CARCINOMA
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Cho Nam-Pyo
Ryu Sun-Youl
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Abstract
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A series of 26 patients with primary oral squamous cell carcinoma(SCC) who were treated from 1988 to 1993 at Chonbuk National University Hospital, were evaluated by flow cytometry, immunohistochemical analysis of p53 and PCNA, new malignancy grading system, and the TNM classification. Our purpose in this study was to determine the prognostic value of the above parameters and their correlation.
Abnormal DNA content (aneuploidy) was identified in 15(58%) of the 26 neoplasms. Abnormal DNA content correlated highly with the tumor size and clinical stage (classified by the TNM classification proposed by the American Joint Committee on Cancer). Positive immunohistochemical detection of p53, a nuclear protein involved in the development of numerous human tumors, was accomplished in 21(81%) of 26 primary SCC and in 3 of 11 nonneoplastic epithelial hyperplasia. Positive immunohistochemical detection of PCNA, polymerase delta accessory protein, was accomplished in all primary SCC and nonneoplastic epithelial hyperplasia. The differences of p53- and PCNA-labeled index between primary SCC and nonneoplastic epithelial hyperplasia were statistically sign ificant (P<0.05). Histologic mean malignancy score of the primary SCC was 14.2. But the histopathologic mean malignancy score had no prognostic value except for the significant difference of population means of invasion pattern and invasion stage between aneuploid and diploid groups of SCC.
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KEYWORD
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